Thyroid: Medullary Carcinoma

نویسندگان

  • Yash R. Somnay
  • David Schneider
  • Haggi Mazeh
چکیده

Medullary thyroid cancers (MTC) are rare neuroendocrine tumors arising from the parafollicular C-cells of the thyroid. In this review, we provide a general overview of the classification, pathology, and clinical management of MTC. In the latter half, we survey the underlying genetic framework of MTC and its potential implications within a diagnostic and therapeutic context.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

99mTc-DMSA (V) in detection of metastases of medullary thyroid carcinoma

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid cancer secreting calcitonin (CT) which is the most sensitive and specific tumor marker for MTC. This type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. The aim of this study was to assess the sensitivity and specificity of [99mTc-DMSA (V)] whole body ...

متن کامل

Imaging of medullary thyroid carcinoma with Tc-99m (V) DMSA [Persian]

Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia ...

متن کامل

تغییرات پلاسمایی استئوکلسین و پروتیین شماره چهار اتصالی رتینول در بیماران با کارسینوم مدولاری تیرویید

Background: Thyroid carcinoma is the most frequent malignant tumor of the endocrine system in human body and accounts for nearly 1% of all cancers. Medullary thyroid carcinoma is the third frequent of thyroid cancer and accounts about 5-8% of thyroid cancer. Osteocalcin, known as a Bone Gamma-carboxyglutamic Acid-containing Protein (BGLAP), is the most non collagenous protein. Retinol binding p...

متن کامل

Oncocytic Variant Of Medullary Thyroid Carcinoma - A Case Report

Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than 20 cases reported. Here we present the case of a 36-year-old male patient with complaints of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC), a Hürthle cell neoplasm was suggested. Finally with histopathol...

متن کامل

Medullary Thyroid Cancer: A Review

Thyroid cancer is a malignancy of the thyroid parenchymal cells. There are four main types of thyroid cancer: papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid carcinoma (ATC), and Medullary thyroid carcinoma (MTC). Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor of the thyroid gland derived from parafollicular C-cells that produce calcitonin (CT...

متن کامل

Axillary lymph node metastasis in medullary thyroid carcinoma: A case report

Introduction: Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare.  Case Report: The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck dis...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2013